I am a great fan of the Comic Life application and have used it quite a few times at work to create comics for handouts, flyers and pages in our staff newsletter.
Comic Life 2 for Mac has been out for a while but the special introduction price of £13.99 ends on the 1st August. So if you like the idea of creating comics and have a Mac then Comic Life 2 is a great piece of software that makes it easy and fun.
Turn your photos into comic layouts (even entire books!) with Comic Life. Speech balloons, fonts and filters give you all the tools you need to make the perfect photo comic.